Availability and reproduction of artificial membranes are limited and therefore problematic
PermeaPad® is a bio-mimetic membrane that simulates the passive mass transport through various barriers in the body (GIT, buccal; nasal). The membrane was developed to provide an option to gain consistent and reproducible results. The time invested in procuring and preparing ex vivo tissues can be spent more effectively. Moreover, no pre-treatment is necessary as the PermeaPad® Barrier is ready-to-use. The Membrane is also very robust, stable against solvents and biorelevant solutions. It is storable at room temperature. The PermeaPad® Barrier offer benefits to users with their experiment in Franz-cells, side-by-side cells or other permeation setups, within manual or automated systems.
The PermeaPad® Plate was developed for customers who have to perform high-throughput screening and need a suitable tool. The 96-well plate with integrated PermeaPad® membrane can be used for the screening and ranking of new active substances (NCEs) and formulations. Furthermore, combined assays can be performed with the PermeaPad® Plate to determine dissolution and permeation rate. The three-part microtiter plate (bottom plate; insert plate with integrated PermeaPad® membrane and cover plate) makes handling very easy and suitable for robot platforms. As with the PermeaPad® Barrier, pre-treatment of the membrane is not necessary. Due to the robustness of the membrane, liquids and environmental parameters can be selected in such a way that they can simulate in vivo situations.